Clemastine

 Clemastine Tablets
 Clemastine (Clemastine) is a drug that is the H-1 histamine blockers derivatives pirollina.

Pharmacological properties

Clemastine exerts influence on the organism, reduces manifestations of allergic reactions. Also it works as a remedy for itching antiexudative and antihistamine.

Step H-1 histamine blockers:

  • decrease vascular permeability;
  • hindering the development of edema;
  • sedation;
  • preventing the contraction of smooth muscle and the development of validation;
  • decrease itching.

Clemastine is also acts as a local anesthetic. It does not cause drowsiness.

The results obtained experimentally show that the drug is not carcinogenic, mutagenic or teratogenic effects. When administered to rats clemastine dose exceeding 312 times the recommended for adults, found that the drug has a negative impact on their fertility.

Maximum antihistaminic effect of the drug is achieved within 5-7 hours, then stored for an additional 10-12 hours.

Product form

Clemastine drug is available in tablet form and syrup to form a solution for injection.

Indications clemastine

Clemastine syrup and tablets administered in cases where there is:

  • hay fever;
  • allergic rhinitis;
  • hives;
  • dermatosis accompanied by itching;
  • eczema;
  • contact dermatitis;
  • allergic to other drugs;
  • reaction to insect bites.

Clemastine in the form of injections administered in cases where there is:

  • angioedema;
  • anaphylactoid reactions;
  • serum sickness;
  • hemorrhagic vasculitis;
  • an allergic reaction or pseudoallergic (as a preventive measure);
  • Acute iridocyclitis.

Instructions clemastine: Dosage and administration methods

Take Clemastine before meals twice a day. The daily dose of 2 mg, and can be increased in some cases up to 3-6 mg. For children calculated from the age of the patient:

  • children from one year to six years twice a day (morning and evening) provide in the form of Clemastine syrup at 0, 67 mg per reception (one teaspoon);
  • for children from six to twelve years prescribed take 1 mg per day (twice a day for 0, 5 mg).

Intramuscular and intravenous injections made using 2 mg at a time twice a day (morning / afternoon).

Babies Clemastine administered intramuscularly, starting from 25 mg / kg / day. This dose is divided into half and administered in the morning and evening.

For breeding the powdered medicine is used a 9% NaCl solution or a 5% dextrose solution in a ratio of 1: 5.  Clemastine injection

Features reception

Instructions clemastine require especially careful monitoring for the elderly and children during the reception of the drug, due to the increased sensitivity of patients in these age groups to medicines antihistamine action.

Intra-arterial injection of the drug possible.

The solution for injection includes at ethanol. Patients taking Clemastine can not drink alcohol, because the drug enhances its effect.

If necessary, take a sample from the scarified skin on the drug allergens canceled up to 3 days (72 hours) prior to the date of testing (in order to avoid data corruption).

Drivers of vehicles and people engaged in potentially hazardous activities, while taking the drug should be very careful because of the possibility they have of slowing of psychomotor functions.

Interaction with other drugs clemastine

With simultaneous use of clemastine with drugs, antipsychotic drugs, which have sedative, hypnotic and antipsychotic effects, drugs used for general anesthesia and other drugs that contribute to central nervous system depression, and alcohol, it enhances their effects on the body.

Clemastine is flatly inconsistent medication with MAO inhibitors and ethanol.

Overdose

According to the instructions to clemastine, an overdose in children may occur: dry mouth, deterioration of motor coordination, hallucinations, fever, increased arousal, lack of reaction of pupils to light, seizures, depression, disorders of the heart and respiration until death. In case of overdose in adults may be: drowsiness, collapse, CNS depression, coma.





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