Celebrex

Celebrex - a drug  Packing Celebrex
 a drug belonging to the group of nonsteroidal anti-inflammatory drugs.

Pharmacological action

Celebrex inhibits predominantly COX-2 and thus has a minimal effect on the activity of COX-1. The drug has anti-inflammatory, antipyretic and analgesic effect.

Experiments on animals have shown that the use of Celebrex significantly reduces the incidence of colon cancer.

Review Celebrex significantly lesser degree than other nonsteroidal antiinflammatory drugs promotes gastroduodenal ulcers and related complications. These data were confirmed by endoscopic examination carried out repeatedly.

Clinical studies have also shown that the use of celecoxib in a dose of not more than 1, 2 g per day did not cause changes in blood coagulability.

The instructions to Celebrex noted that the drug increases the risk of several non-fatal heart attacks and strokes, but does not affect the death rate from cardiovascular disease.

Celebrex is very well absorbed from the gut. The maximum blood concentration is achieved in two hours after oral administration. Fatty foods impairs the absorption of the drug. Excreted in the bile.

With the appointment of therapeutic doses of Celebrex, higher concentrations of the drug in the blood have been reported in women, patients with low body weight and blacks. Therefore, this category of patients, treatment is initiated with minimal doses.

Review Celebrex in some cases can lead to a decrease in discharge (excretion) of sodium excretion, leading to the development of peripheral edema. However, high blood pressure is observed. These swellings do not require treatment and tested independently.

During studies embryotoxic and teratogenic effects of the drug were found.

Celebrex: indications for use

This drug can be used as a symptomatic agent in the treatment of the following diseases:

• Spondylitis;

• Deforming osteoarthritis;

• rheumatoid arthritis;

• Algomenorrhea.

The indication for Celebrex is the severe pain, the development of which is due to trauma, surgery or other causes.

According to the instructions Celebrex can be used for complex treatment of patients with familial adenomatous polyposis. Application of celecoxib in this case helps to reduce the size and the total number of adenomatous colorectal polyps.

Celebrex: instructions for use

This medication is recommended to take two times a day 200 mg. Considering that the development of complications in the cardiovascular system is directly dependent on the dosage of the drug, short duration Celebrex should be administered in courses and minimum effective dose.

Arthritis and other diseases of the joints daily dose of Celebrex may be increased to 800 mg per day.

In acute pain initially administered 600 mg celecoxib, then allowed to 200 mg every 12 hours.

When familial adenomatous polyposis drug is given twice daily 400 mg.

In the appointment of Celebrex in elderly patients weighing less than 50 kg is necessary to reduce the dosage.

Indications Celebrex should be carefully evaluated in patients with severe hepatic insufficiency. The appointment of the drug, its dosage in these patients should be reduced by 50%.

side effects

• Allergic reactions;

• Thrombocytopenia;

• Anxiety;

• Cardiac arrhythmias;

• arterial hypertension;

• noise in ears;

• Alopecia.

In the opinion of Celebrex rarely leads to an increase in liver transaminases and the development of pancreatitis.

With long-term (over 3 years) use of Celebrex may develop:

• arterial hypertension;

• The fragmented fungal infections;

• Disorders of the chair;

• cardiac ischemia;

• ear infections;

• Dysphagia  Celebrex Capsules
 and nausea;

• Prostatitis;

• Education calculi (stones) in the kidney;

• Increase in serum creatinine.

Contraindications Celebrex

• Individual intolerance to the drug;

• Allergic reactions to sulfonamides.

Just Celebrex should not be prescribed for the relief of pain after surgery for coronary artery bypass surgery.

Pregnancy

Indications Celebrex in pregnant women should be carefully evaluated by physicians. This drug can be administered only if the intended use of the therapy would be significantly greater than the potential risk of disease in the fetus.

In the last trimester of pregnancy, Celebrex is contraindicated, since He can break the contractile activity of the uterus during childbirth and lead to premature closure of foramen ovale.

Celebrex interaction with other drugs

Celebrex should not be administered concurrently with indirect anticoagulants and other non-steroidal anti-inflammatory drugs, because it increases the risk of bleeding. Celebrex reduces the antihypertensive effect of angiotensin II.

Overdose

No specific antidote, therefore, for the treatment of symptomatic therapy aimed at maintaining vital functions and Celebrex accelerated clearance from the body of the patient.

Product form

Celebrex is available in capsules containing 100 mg and 200 mg of the active substance (celecoxib). The capsules are packaged in blisters 10 and 20 units.

Analogs of Celebrex

Similarly, the therapeutic action of this drug has other drugs (analogs Celebrex) Celecoxib, Revmoksib, Flogoksib-Health Ranseleks. Analogs of Celebrex have exactly the same indications and contraindications to the appointment, as does Celebrex.

storage conditions

Celebrex should be stored in a dry place, away from children at room temperature.

Additional information about Celebrex

In the opinion of Celebrex may increase the risk of thrombosis, so it is desirable to conduct therapy with minimal doses and for a short period of time. The drug has no anti-platelet properties and can not substitute for acetylsalicylic acid (Aspirin).

The instructions to Celebrex emphasized that in the course of treatment is necessary to monitor blood pressure, especially in elderly patients.

Do not use this drug in pediatric patients because not currently collected sufficient evidence about its safe use in children.

Celebrex is well into the breast milk and can be harmful to the health of the child. Therefore, the period of treatment should abandon breastfeeding.





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