Aprovel (international name - Irbesartan) drug from the group of angiotensin receptor antagonists II, used to treat hypertension.
Structure and Composition
The active ingredient of the drug - irbesartan.
Aprovel available in tablet form at 150 and 300 mg. Tablets biconvex shape, oval, substantially white.
Pharmacological action Aprovelya
Aprovel lowers blood pressure, virtually no effect on heart rate. The maximum reduction in blood pressure observed after 3-6 hours after ingestion. The antihypertensive effect lasts for 24 hours.
A single dose of the drug (150 mg) gives the same effect as receiving 75 mg twice. According to the instructions Aprovelyu, hypotensive action develops within 1-2 weeks from initiation of the drug. The maximum effect of the drug is achieved within 4-6 weeks of therapy.
In case of cancellation after prolonged treatment Aprovelya hypotensive effect is maintained for some time. Withdrawal from the drug is absent.
Aprovel and its metabolites are excreted in the bile and urine. In patients with impaired renal function (including who held a session of hemodialysis) indicators do not change the pharmacokinetics of the drug.
According to the instructions Aprovelyu, testimony to his appointment are:
- hypertonic disease;
- Nephropathy with hypertension and diabetes mellitus (type 2).
In the opinion of Aprovel well in the combination therapy of hypertension in patients with diabetes.
Giperchustvitelnost to any component of the drug, pregnancy, lactation.
Application Aprovelya during pregnancy is contraindicated. In one category trimester fetal exposure (by FDA) - C (i.e. drug research on animals revealed adverse effects on the fetus). On 2 and 3 trimesters of pregnancy category effects on the fetus - D (ie, there is evidence of risk of adverse effects on the fetus Aprovelya).
If pregnancy occurs during treatment Aprovelem, the drug should be abolished as soon as possible.
If breastfeeding women, appointed the drug, at the time of treatment should stop breastfeeding (not known whether Aprovel eksretiruetsya into breast milk).
According to the instructions, Aprovel should be used with caution under the age of 18 years (safety studies have not been conducted).
In the case of using Aprovelya may arise following side effects:
- headache, dizziness, anxiety state (less than 1% of cases);
- tachycardia (rapid heart rate) - less than 1%;
- dyspepsia (nausea, vomiting, diarrhea, heartburn, etc.) - less than 1%;
- myalgia (muscle aches), bone pain, or chest - less than 1%;
- allergic reactions (rash) - less than 1%;
- Other (urinary tract infections, abdominal pain) - less than 1%.
In the opinion of Aprovel well tolerated and rarely causes adverse reactions.
Instructions Aprovelya: Dosage and administration
The drug is taken orally, regardless of the meal, once a day.
According to the instructions Aprovelya initial dose of 150 mg, the dose may, if necessary, be increased to 300 mg per day. In patients with impaired renal function (as well as in patients on dialysis) initial dose of 75 mg per day. In patients older than 75 years Aprovelya starting dose is 75 mg as.
When treating patients with hypertension and diabetes mellitus (type 2) Aprovelya initial dose of 150 mg per day, then it can be gradually increased up to 300 mg (this is the optimal dose for maintenance therapy nephropathy). The proofs of the beneficial effects of the drug on the kidneys in patients with diabetes.
According to reviews, Aprovel has a good antihypertensive effect even in patients with severe hypertension.
In overdose Aprovelya marked hypotension (low blood pressure) may cause tachycardia (rapid heart rate), less bradycardia (slowing of heart rate).
Treatment of an overdose of this drug is reduced to gastric lavage, purpose enterosorbents (such as activated charcoal), symptomatic therapy. Hemodialysis in overdose Aprovelya not effective.
Interaction Aprovelya with other drugs
Irbesartan (Aprovel) compatible with other antihypertensive drugs, and can be used in treatment. Keep in mind that thiazide diuretics (diuretics) enhance the effect of the drug. Prior diuretic treatment increased the risk of hypotension (low blood pressure) at the beginning of treatment Aprovelem. In combination with potassium-sparing diuretics and potassium supplements increase the risk of hyperkalemia.
With the simultaneous use of NSAIDs (eg, ibuprofen, etc..) Can be marked weakening of hypotensive effect Aprovelya. Also, the combined use of these groups of drugs increases the risk of renal impairment (there is a possibility of acute renal failure), particularly in those patients whose renal function was already compromised. When assigning this combination of drugs is required laboratory monitoring renal function.
Aprovel does not affect the pharmacokinetics of cardiac glycosides.
According to the instructions, Aprovel used cautiously in patients with diarrhea, vomiting, as well as in the treatment of diuretic. Patients with renovascular hypertension (caused by renal artery stenosis) increased risk of renal failure and severe hypotension. In patients with severe heart failure and coronary artery disease in the treatment Aprovelem increased risk of myocardial infarction.
Aprovel should not be used in patients with primary hyperaldosteronism, in severe renal and hepatic failure and in patients with a recent kidney transplantation (due to lack of clinical experience in these groups).
When using the drug in patients with impaired renal function is recommended to monitor the levels of serum creatinine and potassium levels.