Aminocaproic acid

Pharmacological action

 Aminocaproic acid powder

Aminocaproic acid is antihemorrhagic and hemostatic drug that has a specific hemostatic effect for bleeding related to increased fibrinolysis (the dissolution of blood clots). This drug helps to reduce the capillary permeability and inhibition of fibrinolysis in general. Aminocaproic acid increases the ability of the liver antitoxic, exhibits moderate anti shock and anti-allergic activity. The drug can improve some of the indicators of specific and nonspecific defense with SARS.

After application of the maximum concentration of aminocaproic acid in the blood observed after 2-3 hours. Plasma protein binding is virtually nonexistent. The bulk of the drug is excreted unchanged by the kidneys, and 10-15% biotransformed in the liver. Accumulation of aminocaproic acid occurs only in the case if there is a disruption of the urinary function.

Indications for use of aminocaproic acid

This drug is used when necessary to stop the bleeding with increased fibrinolytic activity of blood and tissue, which accompany the surgical intervention and various pathologic conditions. Thus, aminocaproic acid is effective for bleeding after surgery on the pancreas, lung, prostate, thyroid, as well as premature detachment of the placenta, acute pancreatitis, liver diseases.

Dosing aminocaproic acid

This drug is available in powder form for oral use (1 packet corresponds to 1 g) and a solution of 5% for infusion.

The powder is taken orally during or after meal with sweet water or previously dissolved in it. According to the instructions aminocaproic acid, a single dose of the drug for oral administration is calculated as follows: 0, 1 g are multiplied by the patient's weight in kilograms. The daily dose should be divided into 3-6 techniques it usually corresponds to 5-24 g

Aminocaproic acid for children is calculated by multiplying 0, 05 grams of the drug on the child's weight, but should not exceed 1 gram. The daily dose depends on the age of the child: children up to 1 year appoint 3 g, for children 2-6 years - 3-6 tea bags; children 7-10 years of age may take the drug in an amount of 6-9 g; over 10 years - 10-15, the

 Aminocaproic acid

The daily dose of aminocaproic acid for children divided into 3-5 receptions.

In the case of acute hypofibrinogenemia aminocaproic acid in solution form is administered at a dose of 100 ml by intravenous drip, repeated administration, if necessary after 4 hours.

Aminocaproic acid in the nose

To prevent influenza aminocaproic acid is used in the nose, which is due to the ability of the drug to strengthen the blood vessels in the nasal sinuses, reducing the risk of bleeding and increase blood clotting. This method of use of the drug is based on its anti-edema and anti-allergic effect, and ability to reduce the amount of bleeding from the nose. Appointment of aminocaproic acid in the nose allows the body and disrupt the interaction of the virus.

Recommended use of a 5% solution of aminocaproic acid as follows: 2-3 nose drops four times a day for preventive purposes, and every 3 hours during the treatment. The course - 3-7 days. Aminocaproic acid in the nose is not contraindicated for pregnant women (3 drops 3 times a day), but before the application is necessary to consult a doctor.

Side effects

The instructions to the aminocaproic acid contain the following negative consequences:

- Fibrillation, bradycardia, subendocardial haemorrhage, orthostatic hypotension;

- Diarrhea and nausea; convulsions, tinnitus, dizziness, headaches;

- Skin rashes, acute renal failure, catarrhal phenomena of the upper respiratory tract.

Contraindications

The use of aminocaproic acid is unacceptable when:

  • tendency to thrombosis and embolism;
  • disseminated intravascular coagulation;
  • Hereditary thrombophilia and secondary;
  • gross hematuria;
  • hypersensitivity;
  • severe renal impairment;
  • breastfeeding;
  • pregnancy.

Additional Information

Storage aminocaproic acid should be in a dry place at a temperature not exceeding 25 0 C. Shelf life - 2 years.





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