In group membership Aminazin refers to antipsychotics. International name - chlorpromazine. It is produced in the form of tablets, coated tablets, dragees and injectable solution.
Mode of action of chlorpromazine
This drug belongs to drugs that have a central nervous system inhibitory effects when applying the recommended doses do not cause hypnotic effects, that is a representative of neuroleptics. Despite the fact that the list of neuroleptic drugs is constantly updated with new tools, Aminazin widely used in medical practice today.
One of the main effects of the drug is a sedative effect of chlorpromazine, which is a calming influence on the central nervous system. Increasing the dose of the drug is not only the growth of total calm, but the oppression motor-defensive reflexes, decrease in motor activity and to some extent the relaxation of skeletal muscles. Despite the fact that after application of high doses of chlorpromazine in reduced reactivity with respect to external and internal stimuli, consciousness is retained. Aminazin while admission to anticonvulsants enhances the action of the latter, however, in some cases, possible seizure phenomena.
The effect on the emotional sphere of rights and antipsychotic effects of chlorpromazine are the main features of the drug. With the possible removal of chlorpromazine agitation, weakening or complete relief of delusions and hallucinations, reduction or removal of fear, anxiety, stress in patients with neuroses and psychoses.
Blocking the action of chlorpromazine aimed at adrenergic (react to adrenaline and noradrenaline) and dopaminergic (involved in the processes of motor coordination and modulation of neuroendocrine signals) receptors. This drug is capable of totally or partially eliminate the effects caused adrenomimeticheskim substances and adrenaline, including increased blood pressure. However, this action does not apply to chlorpromazine eliminate hyperglycemic effect of epinephrine causes an increase in blood sugar levels. In a relatively low degree of ability of the block expressed cholinergic receptors, which are able to convert their interaction with acetylcholine in muscle contraction, nerve impulses and other special effects.
Aminazin soothes hiccup and provides antiemetic effect. The ability of the drug to reduce the body temperature (hypothermic effect) is particularly pronounced while cooling the body artificially. In some cases, affecting thermoregulation centers, the use of chlorpromazine can cause a rise in temperature. The drug also has a mild anti-inflammatory and antihistamine properties, is able to reduce the permeability of blood vessels, reduce the activity of hyaluronidase and kinins. Chlorpromazine enhances the effect of the use of hypnotics, analgesics and local anesthetics.
Indications for use of chlorpromazine
This drug has been used successfully to treat the following diseases:
- Chronic hallucinatory-paranoid and paranoid state;
- manic agitation in patients with manic-depressive psychosis;
- psychotic disorders in patients with epilepsy;
- agitated depression in patients with manic-depressive psychosis;
- neuroses and mental diseases accompanied by insomnia, fear, excitement, tension;
- neurological diseases accompanied by increased muscle tone;
- removal of status epilepticus, if other treatments are not effective;
- vomiting of pregnancy;
- Meniere's disease;
- in cancer radiation therapy, in the treatment with chemotherapeutic drugs;
- pruritic dermatoses.
According to the instructions, Aminazin may be combined with analgesics for persistent pain syndrome, as well as tranquilizers and sleeping pills - for insomnia.
Instructions for use of chlorpromazine
This drug can be administered orally, and injected intramuscularly (i / m) or intravenously (w / w).
According to the instructions, Aminazin Inside designate an adult as follows: 3-4 times a day for 10-100 mg, and the daily dose should not exceed 25-600 mg. Children older than 5 years allowed the use of 1 / 3-1 / 2 of the adult dose. For children 1-5 years, a single dose is calculated by multiplying the 500 micrograms of the drug on the child's weight to be taken every 4-6 hours. A more accurate dosing schedule determined by the attending physician depending on the evidence, the patient's condition, age, and other factors.
The instructions to chlorpromazine indicated that when a / m a single dose administered should be 0, 15 g, and the daily - 0, 6, the other is not assigned, then the / m administered from 1 to 5 ml of 2, 5% solution number of administrations should be not greater than three per day. In the case of acute mental excitation Chlorpromazine application occurs in / method: 2-3 ml of dilute 20 ml of 40% glucose solution. Maximum allowable dose treatment with / in a not exceed 0, 1 g and daily - 0, '25
The instructions to chlorpromazine specified list of diseases in which the use of this drug is unacceptable:
- abnormalities in the kidneys and liver;
- irregularities in the functioning of the blood-forming organs;
- progressive disease of the brain and the spinal cord of a systemic nature;
- thromboembolic disease;
- decompensated heart defects.
Relative contraindications to the use of chlorpromazine are: rheumatic heart disease, rheumatic fever, acute pyelitis, urolithiasis and cholelithiasis.
Contraindications taking the drug orally for stomach ulcers and duodenal ulcers, in which case you should use the intramuscular route of administration.
Not assigned Aminazin in the following cases:
- unconscious patient;
- acute brain injury;
According to the instructions of chlorpromazine, use of the drug can cause a number of negative consequences:
- blurred vision, akathisia (inner sense of motor restlessness), parkinsonian syndrome, thermoregulation disorders, convulsions (in rare cases);
- tahakardiya, and at / in the introduction - hypotension;
- when the use of chlorpromazine into possible digestive disorders as heartburn, nausea, diarrhea, etc .;
- agranulocytosis, leukopenia;
- difficulty urinating;
- weight gain, impotence, menstrual disorders, gynecomastia;
- itching, skin rash;
- neuroleptic depression.
According to the instructions, Aminazin should be stored in a dark place where the temperature does not exceed 25
C. Shelf life is 2 years.