Amikacin

 Amikacin - Solution for intravenous administration
 Amikacin - an antibacterial agent from the group of aminoglycosides.

Release form and composition

Amikacin is produced in powder form and ready solution for intramuscular and intravenous administration.

The active ingredient in the composition of the drug acts in the form of amikacin sulfate (1 ml - 250 mg). Supporting components are:

  • Sodium bisulfite;
  • Sodium citrate for injection;
  • Water for Injection;
  • Sulfuric acid dilution.

The solution formulation is available in glass vials 4 ml. Blisters containing 5 or 10 vials funds. In a cardboard unit 1 or 2 packages.

Amikacin Powder for solution is available in bottles of 10 ml. One cardboard boxes containing 1, 5 or 10 vials.

Indications

According to the instructions, Amikacin is used for:

  • Bronchitis;
  • Endocarditis;
  • Lung abscess;
  • Pneumonia;
  • Empyema;
  • Sepsis;
  • Infection of the central nervous system;
  • Septic endocarditis;
  • Pyelonephritis;
  • Urethra;
  • Cystitis;
  • Gonorrhea;
  • Prostate;
  • Peritonitis and other infections of the abdomen;
  • Purulent infections of the skin and soft tissues;
  • Biliary tract infections, joint and bone;
  • Otitis;
  • Postoperative infections.

Contraindications

According to the instructions, Amikacin is contraindicated in:

  • Neuritis of the auditory nerve;
  • Hypersensitivity to agents (including other aminoglycosides);
  • Severe chronic renal failure;
  • Pregnancy.

Caution should be used when an antibiotic Parkinsonism, myasthenia gravis, dehydration, during lactation and in the elderly.

Furthermore, under strict medical supervision give Amikacin newborns and premature babies.

Dosage and Administration

Amikacin intramuscularly or intravenously administered every 8 hours of 5 mg / kg every 12 hours or at 7, 5 mg / kg.

In uncomplicated bacterial infections afflicting the urinary tract, shows the use of Amikacin every 12 hours 250 mg.

Preterm newborn children drug is administered in a dosage of 10 mg / kg, followed by moving to 7 dose, 5 mg / kg, which is administered every 18-24 hours.

Healthy newborns is administered at an initial dose of 10 mg / kg, followed by moving to 7, 5 mg / kg every 12 hours for 7-10 days.

The maximum tolerable daily dosage for adults - 15 mg / kg / day.

In intramuscular therapy lasts 7-10 days, and intravenous - 3-7 days.

Side effects

Amikacin in some cases may cause the following side effects:

  • Nausea;
  • Vomiting;
  • Disorders of the liver and kidneys;
  • Leukopenia;
  • Thrombocytopenia;
  • Anemia;
  • Granulocytopenia;
  • Headache;
  • Numbness;
  • Tingling;
  • Muscle twitching;
  • Seizures;
  • Stop breathing;
  • Hearing impairment (including irreversible deafness);
  • The labyrinth and vestibular disorders;
  • Incoordination;
  • Fever;
  • Hyperemia;
  • Itchy skin and rashes.

When using high doses of amikacin possible violation of urination and breathing, hearing loss and appetite, ataxia, dizziness, thirst, vomiting, ringing in the ears.

When drug poisoning is carried out peritoneal dialysis and hemodialysis, mechanical ventilation is administered calcium and anticholinesterase drugs.

Cautions

For intravenous use Amikacin concentration of its active ingredient in the solution should not exceed 5 mg / ml.

In drug treatment is recommended at least 1 time in 7 days to monitor the function of the auditory nerve, kidney, and the vestibular apparatus.

In a joint reception with Amikacin benzylpenicillin enhanced effect of both drugs. Especially effective is a combination of the treatment of infection by strains of fecal enterococcus.

The drug should not be combined with heparin, penicillin, amphotericin B, capreomycin, erythromycin, vitamins B and C, calcium chloride, hydrochlorothiazide, cephalosporins.

Nephrotoxicity and ototoxicity enhance Amikacin cisplatin, nalidixic acid, polymyxin B, vancomycin.

In turn, reduces the effectiveness of antibiotic drugs for myasthenia gravis.

Analogs

Analogues of amikacin powder formulations are: Amikacin-Vial, Amikacin-Verein and Amikabol.

Analogues of funds in the form of a solution are: Selemitsin and Hematsin.

Terms and conditions of storage

Amikacin should be stored in a dry place out of reach of children, protected from direct sunlight at a temperature of 5-25 ° C.

Shelf life is 2 years.





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