Acetylcysteine - a synthetic drug, vasoconstrictor and mucolytic effect, used to treat ENT diseases.
The active substance acetylcysteine helps liquefy mucus and increase in its volume. The drug, exerting vasoconstrictor and mucolytic effect, promotes and facilitates expectoration sputum. In addition, according to the instructions acetylcysteine has an antioxidant effect.
Acetylcysteine is produced in the form of tablets, solution for inhalation and a solution for injection. The drug is available under various brand names - acetylcysteine, NAC, Rinofluimutsil, Atsestin Weeks asset, the AD FS Mukoneks, Fluimucil. Analogs Acetylcysteine is available in different dosage forms:
- Effervescent tablets - Atsestin, ACC, ACC Long, Fluimucil, H-AC-Ratiopharm;
- Nasal Spray - Rinofluimutsil;
- Tablets - Atsestin;
- Solution for injection - ACC injective, Fluimucil;
- Granules for syrup - Mukoneks, ACC;
- Granules and powder for oral solution - NAC, Acetylcysteine-Sedico, Fluimucil, H-AC-Ratiopharm.
Indications for use of acetylcysteine
Acetylcysteine on the instructions prescribed for respiratory diseases and conditions, which are accompanied by the formation of muco-purulent and viscous sputum:
- Acute and chronic bronchitis;
- Trachea, resulting bacterial or viral infection;
- Bronchial asthma;
- Sinusitis - to facilitate the discharge of secretions;
- Cystic fibrosis, in combination therapy;
- Atelectasis caused by occlusion of the bronchi of the mucous plug.
Acetylcysteine is also indicated for post-traumatic and postoperative conditions for the removal of viscous secretions from the respiratory tract.
According to the instructions acetylcysteine contraindicated apply at:
- Gastric ulcer and duodenal ulcer in the acute phase;
- Pulmonary hemorrhage;
- Coughing up blood;
- Hypersensitivity to the active substance acetylcysteine.
The use of acetylcysteine during pregnancy and breastfeeding is possible only under strict conditions.
In bronchial asthma, and diseases of the adrenal glands, kidneys and liver acetylcysteine should be used with caution. The drug under the strict supervision of a physician on the testimony can be used in neonates.
Adults and children over 14 years are usually given 600 mg acetylcysteine, which can be taken as a one-off, and dividing by three steps. For children 6-14 years, the daily dose should not exceed 400 mg. Children 2-5 years should receive acetylcysteine as effervescent tablets of 200-300 mg per day, divided into several times.
For colds acetylcysteine take 5-7 days. In severe cases the duration of the drug is determined individually by your doctor. Treatment of bronchitis and cystic fibrosis requires a longer use of the drug.
Acetylcysteine as a solution for injection administered intramuscularly once a day for adults - 300 mg, for children - 150 mg. Acetylcysteine used for inhalation of 2-5 ml of 20% solution for 15-20 minutes.
If necessary, use analog acetylcysteine should consult a doctor.
Do not be taken simultaneously with acetylcysteine antitussives due to suppression of the cough reflex, which can lead to stagnation of phlegm. Between taking antibiotics and acetylcysteine should observe an interval of at least 1-2 hours.
Side effects of acetylcysteine
Using drugs and analogs acetylcysteine side effects are rare. Most often, the drug according to instructions is:
- Heartburn, nausea, vomiting, diarrhea, sensation of fullness;
- Nasal bleeding and tinnitus;
- Skin rash, itching, hives, bronchospasm.
When using acetylcysteine inhalation possible local irritation of the respiratory tract, cough reflex and, much more rarely, stomatitis or rhinitis. In applying the drug to be injected at a shallow intramuscular injection may appear slight burning sensation.