Aceclidine

Aceclidine - active cholinomimetic with a mitotic effect.

 Aceclidine formula

Method of production and composition aceclidine

  • The solution was 0, 2% hypodermic injection ampule 1 or 2 ml;
  • A solution for eye drops, 2, 3, or 5%. Active ingredient - aceclidine, respectively 2, 3 or 5 g;
  • Eye ointment atseklidinovaya 3 or 5%. The active ingredient - aceclidine respectively 3 or 5, the auxiliary components - mineral oil, petrolatum, anhydrous lanolin.

Medicinal properties aceclidine

The active substance and tone increases peristalsis intestine, bronchi, uterus, bladder, increases salivation. It has a pronounced effect on M-cholinergic receptors. A distinctive feature of the drug is a strong myotic effect that the duration and potency superior to pilocarpine.

Indications aceclidine

Aceclidine of instructions used in ophthalmology for instillation into the eye as miotikami to reduce intraocular pressure and pupil constriction in glaucoma.

In gynecology, urology, obstetrics and surgery aceclidine of instructions used to eliminate and prevent atony and paresis of the bladder and the muscles of the gastrointestinal tract in the postoperative period, when weak labor in order to stop bleeding postpartum at subinvalyutsii uterine atony and postpartum .

Method of application and dosage

When atony of the bladder and bowel prescribe aceclidine pp. Putting it subcutaneously with 1-2 ml of 0, 2% solution.

The same dosage as instructed aceclidine used in obstetrics and gynecology.

In the case of weak action or insufficient effect of the use of the drug, the injection is carried out 2-3 times at intervals of 30 minutes. If necessary, the drug is administered for 2-3 days (subinvoljutcija uterus).

In ophthalmology for instillation use water solution of 2%. With little effect used an aqueous solution of 3 or 5%. Also prescribe eye ointment aceclidine.

The solution was used for instillation in the eye 3-6 times per day (depending on the duration of treatment and the therapeutic effect). Atseklidinovuyu ointment before bed lay the edge of the eyelids.

Perhaps the combined use of instructions with aceclidine phosphacol, pilocarpine, eserine and others.

The maximum dosage of prescription aceclidine: 0, 004 g of one-time, 0, 012 grams per day.

Possible side effects aceclidine

With an overdose of the drug, as well as increased individual sensitivity to the drug can: salivation, diarrhea, sweating, a slight decrease in blood pressure with softly pronounced bradycardia.

In practice, the use of eye aceclidine prescription can cause a feeling of heaviness and the "ache" in the eyes. These side effects can be removed through the use of injection anticholinergics - Metacin, atropine, and others.  Aceclidine - solution is to bury the eyes

Contraindications aceclidine

Application aceclidine prescription contraindicated:

  • When pregnancy;
  • Hyperkinesia;
  • In the case of gastric bleeding;
  • In inflammatory processes in the abdominal cavity.

Not allowed parenteral administration of the drug in bronchial asthma, severe organic heart disease, epilepsy, atherosclerosis, angina.

Cautions

In the case of the instillation solution in the eye, it is recommended for a few minutes to press the area of ​​the lacrimal sac, so that the solution was in the nasal cavity and in the area of ​​the tear duct.





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