Isoptin - synthetic antianginal drug used in the treatment of angina pectoris and arrhythmias as well as for reducing blood pressure.
The active substance of Isoptin has a hypotensive, antiarrhythmic and antianginal effects.
Isoptin related to antiarrhythmic drug group IV. Also, preventing vasoconstriction, it is used as a preventive agent for headache.
When administered intravenously, takes effect almost immediately, ingestion - 1-2 hours. Duration - 8 hours to days.
Isoptin produced in the form of capsules, dragees, solution for intravenous injection, and tablets.
A solution for intravenous administration produced in 2 ml ampoules. Each vial contains 5 mg of verapamil hydrochloride. 5, 10, 50 ampoules per carton box.
The tablets are available in different dosage and mode of action:
Isoptin - White round biconvex, film-coated tablets, each tablet contains 40 mg (40 Isoptinum - engraved with "40" on one side) and 80 mg (engraved with "ISOPTIN 80") of the active substance verapamil hydrochloride. Other ingredients: magnesium stearate, calcium hydrogen phosphate dihydrate, microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide. 10 pieces in blister, 2, 10 blisters in carton; 20 pieces in blister, 1, 5 blisters in a carton box.
Isoptin SR 240 - kapsulovidnye light green tablets prolonged action. Each tablet contains 240 mg of active ingredient verapamil hydrochloride. Other ingredients: glycolic mountain wax, magnesium stearate, povidone K30, microcrystalline cellulose, sodium alginate, purified water, quinoline yellow, hypromellose, macrogol 400, talc, macrogol 6000, titanium dioxide, indigotin. 10 pieces in blister, 1, 2, 3, 5, 10 blisters in carton; 15 pieces in blister, 5, 10 blisters in carton; 20 pieces in a blister, 1, 2, 3, 5, 10 blisters in a carton.
The closest analogue of Isoptin - Verapamil, which is also produced in the form of tablets and solution for injection.
According to the instructions Isoptin is used for:
- Primary hypertension in the "small" circle of blood circulation;
- Chronic stable angina;
- Angina, which is caused by a spasm of blood vessels - Prinzmetal angina or variant;
- Sinus tachycardia;
- Paroxysmal supraventricular tachycardia;
- Atrial tachyarrhythmia;
- Atrial fibrillation, which are accompanied by tachyarrhythmia.
Intravenous Isoptinum of instructions used in hypertensive crisis, to restore sinus rhythm in paroxysmal supraventricular tachycardia (Wolff-Parkinson-White and Lown-Ganong-Levine), as well as for the control of ventricular rate during atrial fibrillation and flutter.
Isoptin has a number of absolute and relative contraindications.
Absolute contraindications include:
- Cardiogenic shock;
- Bradycardia-tachycardia syndrome;
- Complications of acute myocardial infarction;
- Sinoatrial block and AV-block 2 and 3 degrees.
Isoptin is contraindicated for instructions on when:
- Bradycardia at a frequency of less than 50 beats per minute;
- Congestive heart failure;
- Atrial fibrillation with WPW syndrome because of the risk of ventricular tachycardia;
- Systolic blood pressure below 90 mm Hg .;
- AV-blockade of the first degree.
Instructions for use Isoptin
Isoptin as a solution for injection is used only intravenously.
Introduction is performed slowly by controlling the condition of pressure and ECG at least 2 minutes. Elderly time of administration, it is desirable to increase up to 3 minutes. Slow administration significantly reduces the risk of side effects. A single dose of 5-10 mg. In the absence of the expected effect of the introduction of the drug can be repeated at the same dose in half an hour after the start.
Tablets Isoptinum 240 taken during a meal or immediately after a meal, swallowed whole and washed down with water. The average daily dose is 240-360 mg.
In the treatment of chronic stable angina pectoris, angina, which is caused by a spasm of blood vessels, variant angina and Prinzmetal, Isoptin SR appoint 240-480 mg per day. The dose should be divided into 2 doses and taken with an interval of 12 hours.
In the treatment of mild hypertension Isoptin SR appoint 240 mg at one time, in the morning. If you want a slow decline in blood pressure, then start with 120 mg per day. If necessary, increase the dose, it should be done more frequently than every two weeks.
In the treatment of paroxysmal supraventricular tachycardia, atrial flutter or blink, Isoptin 240 appoint 120-240 mg 2 times a day. Observe interval between doses in 12 hours.
The duration of the Isoptinum 240 is not limited.
Isoptin 40 Inside, 40-80 mg for angina and supraventricular tachycardia 3 times a day, with hypertension - 2 times a day. The average daily intake for children up to 5 years - 40-60 mg, 6 to 14 years - 80-360 mg. Dose divided into 3-4 receptions. Children under 2 years with supraventricular arrhythmias appoint 20 mg (poltabletki Isoptinum 40) 2-3 times a day.
The effect of the drug is enhanced with abnormal liver function. Therefore, liver cirrhosis apply Isoptinum 40 assigning 40 mg 2-3 times a day. The daily dose - not more than 120 mg.
Isoptin may cause various side effects: syncope, bradycardia, headache, depression, constipation, nausea, allergic skin reactions, peripheral edema, palpitations, collapse, arrhythmias, pain in joints and muscles, and angina.
Overdose Isoptinum shown a pronounced decrease in blood pressure, shock and bradycardia. Symptoms depend on the dose, the age and condition of the cardiovascular system. Also keep in mind that in the form of prolonged Isoptinum active substance is absorbed from the digestive tract for a day after ingestion.
Admission Isoptin Isoptin SR 40 and is not recommended in pregnancy and during breast-feeding.
Produced by other drugs - analogues Isoptin. Verapamil hydrochloride, beliefs, Atsupamil, finoptin Vepamil, verapamil Sopharma, Danistol, Verogalid EP 240 Verakard, Verapabene, verapamil, verapamil, verapamil Ratiopharm (Mival), verapamil hydrochloride, verapamil-MIC, verapamil-Verein, Lekoptin, Vero verapamil, Verom, Kaveri, Falikard, Falikard Long Isoptinum are analogous chemical composition and therapeutic effect.
Isoptin available on medical prescription. Shelf life - 3 years.