Diflucan - effective drug against most of the known species of yeast and fungi, dermatophytes (affecting hair, nails, and the horny layer of the epidermis) and dimorphic fungi capable of developing both of mold and yeast forms.
The active substance of Diflucan - Fluconazole has a way to suppress fungal cells synthesis of sterols needed for the formation of cell membranes.
Due to the rapid absorption of the maximum concentration in blood of Diflucan observed after 30-90 minutes after application.
The half-life of fluconazole, equal to 26-30 hours, allow to take the drug once a day. For Diflucan characterized good permeability into tissues and body fluids, so the concentration of drug in the bronchial secretions, saliva, cerebrospinal fluid corresponds to the blood concentration. A higher number of fluconazole is accumulated in the stratum corneum.
Virtually unchanged Diflucan excreted by the kidneys.
Assign User Diflucan recommends that:
- cryptococcosis including cryptococcal meningitis and infections of other sites;
- kriptokokoza relapse prevention in immunocompromised patients;
- generalized candidiasis (thrush damage internal organs);
- candidiasis of the mucous membranes;
- Acute and recurrent vaginal candidiasis;
- genital candidiasis;
- prevention of fungal infections in patients with malignancies who radiotherapy and cytotoxic chemotherapy can trigger the development of such infections;
- mycosis of the skin of various localization (the disease caused by parasitic fungi);
- Deep endemic mycoses (with the geographic distribution).
The drug Diflucan reviews described as an effective drug for the treatment of all these diseases.
Instructions for use Diflucan
Diflucan is produced in the form of capsules containing 50 mg, 100 mg or 150 mg of fluconazole, powder for oral suspension and intravenous solution.
Diflucan capsules used in different doses, the magnitude of which depends upon the severity and nature of the disease. Cryptococcal infection, cryptococcal meningitis and invasive (spread throughout the body), candida infections are treated by the administration of 400 mg of fluconazole in the first day and 200-400 mg on subsequent days. The duration of treatment depends on the clinical efficacy of the drug.
Diflucan from yeast to oral mucosa, gums, cheeks, tongue, pharynx used within 1-2 weeks of 50-100 mg daily. Likewise treated and other mucosal Candida infections (except genital candidiasis), only the duration of the use of Diflucan in such cases - 2-4 weeks.
Diflucan for yeast, affecting the vagina, is assigned a single dose of 150 mg. To prevent the recurrence of vaginal candidiasis is possible to use one capsule Diflucan 150 mg once a month for 4-12 months. Also Diflucan 150 mg capsule once recommended for inflammation of the glans penis provoked by fungi of the genus Candida. Prevention of candidiasis involves the appointment of a daily dose at a rate of 50-400 mg.
With infections of the skin and pityriasis versicolor is recommended to take 50 mg of fluconazole daily for 2-4 weeks, with athlete's foot requires a longer treatment - about 6 weeks. Also, when these diseases are possible alternative regimens: infections of the skin appointed Diflucan 150 mg once a week (2-4 times), and in pityriasis versicolor - 300 mg per week (1-3 times).
When the nails mycosis Diflucan 150 mg is recommended to take once a week for 3-12 months to nail replacement patient healthy. Deep endemic mycoses can be treated for 2 years by receiving 200-400 mg per day of Diflucan.
Children diflucan yeast infection of the mucous membranes of the applicable rate of 3 mg of fluconazole per 1 kg of body weight of the child. On the first day of treatment can be taken a double dose to rapidly achieve equilibrium concentrations. Cryptococcal infection and generalized candidiasis contemplate use of 6-12 mg / kg per day. Diflucan for preventing fungal infections in immunocompromised children recommended daily dose of 3-12 mg / kg.
Newborns Diflucan is assigned the same dose as older children, but at other intervals: at the age of two weeks - 1 time in 3 days, at the age of three to four weeks - 1 time in 2 days.
Adverse effects of the drug Diflucan reviews and clinical studies include:
- headache, dizziness, convulsions;
- nausea, flatulence, abdominal pain, vomiting, dyspepsia;
- toxic effects on the liver, abnormal liver function, jaundice, hepatitis. necrosis of hepatocytes;
- agranulocytosis, neutropenia, thrombocytopenia, increased blood cholesterol, hypokalemia.
Reviews Diflyukane show such side-effects, such as itching, facial swelling, rash, hair loss, change in taste.
The use of Diflucan fluconazole prohibited intolerance, as well as while taking terfenadine and cisapride.
Appoint Diflucan instruction is not recommended during pregnancy and breastfeeding, as data on the safety of the drug in these categories of patients are not available. Diflucan can be recommended to pregnant women only for health and nursing - provided the cessation of breastfeeding.
According to the instructions, Diflucan should be stored at a temperature not exceeding 30
C. Shelf life of the drug in capsules and solution for intravenous administration - 5 years. Diflucan powder for suspension deemed fit within 3 years from the date of manufacture, and the finished slurry - 14 days.