Biol - a synthetic drug with antihypertensive effect.
The active substance Biola has antihypertensive effect without its own sympathomimetic activity. As a result of Biola decreased minute volume of blood, reduces the activity of sympathoadrenal and decreases myocardial oxygen demand.
Feedback from Biol has a less pronounced effect on skeletal muscle, pancreas, bronchial smooth muscle and the uterus.
Biol produced in the form of pale yellow round tablets engraved "BIS 5" containing 5 or 10 mg bisoprolol hemifumarate. Other ingredients - calcium phosphate, corn starch, colloidal anhydrous silica, microcrystalline cellulose, croscarmellose sodium and magnesium stearate. 30, 50 and 100 tablets per pack.
According to the instructions Biol used to treat:
- Coronary heart disease, including prevention of attacks of stable angina;
- Chronic heart failure in combination therapy.
Biol contraindicated for instructions apply when:
- Congestive heart failure and chronic heart failure in the stage of decompensation;
- Sick sinus syndrome;
- Severe arterial hypotension;
- Expressed disturbances of peripheral circulation;
- Severe bronchial asthma and chronic obstructive pulmonary disease;
- Raynaud's syndrome;
- Hypersensitivity to the Biola to other beta-blockers;
- AV-block II and III;
- Cardiogenic shock;
- Metabolic acidosis;
- Sinoatrial block;
- Concomitant use floctafenine and sultopride.
Biol not recommended before the age of 18 years. Use of the drug during pregnancy can lead to fetal death, fetal growth retardation, premature birth or miscarriage, as well as the development of pathological reactions, such as fetal hypoglycemia, developmental delay, bradycardia. Therefore Biol apply in this period, as well as through breast-feeding is not recommended.
Biol take with caution in:
- AV blockade of I degree;
- Congenital heart disease;
- Chronic heart failure, myocardial infarction within the last 3 months;
- Renal failure, and abnormal liver function;
- Conducting desensitizing therapy;
- Type 1 diabetes;
- Prinzmetal angina;
- Restrictive cardiomyopathy.
According to the instructions Biol morning on an empty stomach it is recommended to take one tablet a day.
In the treatment of hypertension and coronary heart disease usually take Biol 5 mg once a day. When indications the dosage may be increased to two times, but not more than 20 mg per day.
In chronic heart failure, after the compulsory phase of the special titration under regular medical supervision, treatment is initiated with 1/4 tablets of 5 mg Biola. When the positive dynamics depending on individual tolerance dose can be gradually increased up to 5 or 10 mg per day.
Note that at the beginning of therapy may develop hypotension or bradycardia. In this case, it is recommended to choose the necessary accompanying standard therapy, and also temporarily reduce the dose received Biola.
When kidney disease or liver is usually prescribed a lower dose Biola, the elderly a dose adjustment is required.
In case of overdose of Biola instructions may occur bradycardia, arrhythmia, syncope, marked reduction in blood pressure, dizziness, ventricular premature beats, AV block, acrocyanosis, acute heart failure, hypoglycemia, bronchospasm, difficulty breathing and convulsions.
In an application Biola with antiarrhythmics class 1 and 3, beta-blockers for topical application, including drops for glaucoma treatment, beta-agonists, mefloquine, insulin, ethanol, nifedipine, diuretics, clonidine, sympatholytic, tricyclic and tetracyclic antidepressants, hydralazine, antipsychotics, sedatives and hypnotics may develop unwanted side effects that lead to a change in the therapeutic effect of the drugs.
Side effects Biola
Feedback from Biol often cause bradycardia and palpitations. Besides drug may cause:
- Marked decrease in blood pressure;
- Strengthening of peripheral blood circulation and sensation of cold in the extremities;
- Dizziness and headache;
- Fatigue and sleep disturbances;
- Depression and anxiety;
- Nausea, vomiting, dry mucous membranes of the mouth, diarrhea or constipation, abdominal pain.
Biol reviews for significantly less likely to cause swelling of the ankles and feet, increased frequency of angina attacks, disturbance of AV conduction, arrhythmia, chest pain, orthostatic hypotension, shortness of breath, high blood pressure.
In rare cases, according to the reviews Biol cause confusion, or short-term memory loss, back pain, hallucinations, itching, nightmares, myasthenia gravis, tremor, psoriasis-like skin reactions, conjunctivitis and muscle cramps.
Biol available on medical prescription recommended by the manufacturer of the drug shelf life - 4 years.