Glioblastoma - most
frequent and one of the most insidious brain tumors.
Glioblastoma brain: features, etiology, classification, diagnosis.
Intrigue glioblastoma brain is that its germination in the brain tissue occurs rapidly. Most often it is localized in the forehead and temples; its dislocation is always located in the brain.
Etiology (cause) of glioblastoma multiforme to date not been reliably established. The hypothesis about the negative impact of mobile communications in her appearance was not confirmed. At the same time revealed the following risk factors for glioblastoma:
- men are affected more often than women;
- most characteristic of the disease for people aged 40 to 60 years;
- regular exposure to ionizing radiation or certain chemicals (eg, polyvinyl chloride).
In accordance with the classification of the World Health Organization (WHO) glioblastoma awarded the 4th degree of malignancy.
There are three types of glioblastoma:
- giant cell,
To confirm the diagnosis of brain glioblastoma apply modern informative and highly accurate methods of examination - magnetic resonance imaging (MRI) with the introduction of a contrast agent, and
SPEKT and PET scanning.
It was noted that in some cases the nature of the resulting image may not reflect the severity of the disease. The final analysis in the diagnosis of glioblastoma is a stereotactic biopsy of tumor cells and their postmortem examination.
It is obvious that the development of glioblastoma brain accompanied by intense headache. Patients complain of blurred vision, numbness, drowsiness. An increased intracranial pressure, dizziness. A number of patients recorded seizures. Close human glioblastoma notice memory disorder and personality change. The tragedy of the situation is that before the first symptoms glioblastoma grows to the size of hypertrophied.
Modern approach to the treatment of glioblastoma
Treatment of glioblastoma consists of three stages:
- surgical intervention with a view to completely removing tumors;
- kombinatsiyaluchevoy therapy and medical treatment;
- chemotherapy for maintenance.
removal of glioblastoma allows the duration and quality of life. The difficulty of this stage due to the lack of clear boundaries visible in the background glioblastoma brain inflamed and swollen surrounding tissue.
In the past, radical removal was not possible because the extremely high risk was hurt during neurosurgery functional areas of the brain, causing paralysis, etc. Today, the total resection of glioblastoma used contrast agent - 5-aminolevulinic acid. The operation is performed using a special microscope, having a source of blue glow. Tumor cells were visualized - glow that allows the surgeon to remove it without leaving residue.
The subsequent combination treatment of glioblastoma lasts about 1, 5 months. For five days a week during this period the patient receives radiation dosage, and drug Temodal receives daily without interruption.
A month after the end of radiotherapy receiving Temodal resumes. Supporting course consists of 6 stages, each of which lasts five days. The interval between stages is 23 days.
About 10% of cases for recurrent glioblastoma multiforme. Since 2005, for the treatment of such patients have successfully used the drug Avastin.